FDA Alert Regarding Isoxazoline Medications for Fleas and Ticks

FDA Alert Regarding Isoxazoline Medications for Fleas and Ticks

By Dr. Bob Parrish on Sep 27, 2018

Hello CVPC friends!

Recently, there have been concerns in the veterinary community involving potential problems with a certain class of drugs called Isoxazoline, which is used to treat fleas and ticks. Since there are concerns from pet owners, I felt it necessary to provide information without the social hysteria.

There are currently 4 different prescription-only medications in this class:
– Bravecto
– Credelio
– Nexgard
– Simparica
At Carolina Value Pet Care, we offer Bravecto and Simparica.
We do
not offer Credelio or Nexgard.

While the FDA (Food and Drug Administration) states that they consider these products to be safe and effective*, they have posted an alert for potential adverse neurological/nervous system events in dogs and cats when treated with flea medications in this class.  *Important to note: More than 80 million doses of Bravecto have been distributed in 85 countries since 2015. The reported incidence of neurological signs is very rare (rare is defined as “fewer than 1 in 10,000 cases”).

The majority of pets can take these medications safely. If your pet experiences an adverse effect, it could show up in the form of muscle tremors or spasms, loss of body control and stumbling, or seizures.

If you give any of these medications, and your pet begins to experience any of the nervous system affects (tremors, stumbling or seizures), by all means have your pet seen by a full-service veterinary hospital, or veterinary emergency clinic.  

1) Talk to us! We can discuss using alternative medications for treating fleas and ticks.
2) Contact the manufacturer of the product you are using to inform them of the adverse event. They need that info to learn more about potential side-effects of the drugs they manufacture.

There have been “reports” that these medications cause liver or kidney failure. There is no evidence to support these claims at all and the FDA makes no reference to these internal organs being an issue. However, in my opinion, I would advise you to avoid any medication (not just flea medication) that does not support the liver or kidneys.      

You are welcome to discuss any specific concerns you may have with us via email or by phone (704.288.8620 – Mon-Fri:  8am til 4pm)

Best Regards,

Dr. Bob

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